It's a double blow for the Dutchman after last weeks UEFA Cup disappointment, and one that will put in doubt his future at Boro.
The Boat has been a class act in the red of Boro but his frustrating performance in Eindhoven may just have cost him his ticket to Germany.
Boro must do all they can to keep the midfield general, he will cost millions to replace. The appointment of a new manager must be sorted quickly so that the future of certain players can be resolved in a quick and satisfactory manner.