Boro are still without Michael Reiziger, Malcolm Christie, Stuart Parnaby, Ugo Ehiogu, Szilard Nemeth and recent casualty Gaizka Mendieta.
Franck Queudre returns to European action after missing the game in Athens, while serving a ban, following his dismissal against Banik Ostrava.
The full Boro squad is:
Schwarzer, Queudrue, Southgate, Cooper, Boateng, Zenden, Parlour, Downing, Viduka, Hasselbaink, Job, Riggott, Graham, Morrison, Wheater, Peacock, Nash.
Lazio are also struggling with injuries, although both Simone Inzaghi and the Paolo Di Canio should feature after shaking off knocks.
With several first team players missing manager Mimmo Caso could be forced to bring in youngsters to cover.