The 27 year old has ruled himself out of the fixture after picking up an ankle injury against Charlton 10 days ago.
He expects to be sidelined for three weeks with a return possible in the clash with Manchester City at Maine Road on April 12.
The Dutch international has now suffered three injury setbacks in his first season at the Riverside after a relatively trouble free career.
Boateng's absence may mean Brazilian Doriva is handed his first Premiership start after his loan move from Celta Vigo.